Nuclear localization of prostaglandin E2 receptors
نویسندگان
چکیده
منابع مشابه
Nuclear prostaglandin receptors
Prostaglandins and thromboxane are ubiquitous compounds and play important roles in cardiovascular homeostasis, inflammation, reproduction, respiration, mitogenesis and gene transcription and so on. These actions of prostanoids are presumed to be mediated by plasma membrane receptors belonging to the superfamily of G protein-coupled receptors. However, several lines of evidence suggest prostano...
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246 words Introduction: 534 words Discussion: 2209 words Abbreviations: COX, cyclooxygenase; COX-2, cyclooxygenase-2; TBS, tris-buffered saline; P-gp, P-glycoprotein; BBB, blood-brain barrier; PGE2, Prostaglandin E2; EEG, Electroencephalogram; NMDA, N-methyl-D-aspartic acid; CNS, central nervous system Section: Neuropharmacology This article has not been copyedited and formatted. The final vers...
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Chronic kidney disease is a leading cause of morbidity and mortality in the world. A better understanding of disease mechanisms has been gained in recent years, but the current management strategies are ineffective at preventing disease progression. A widespread focus of research is placed on elucidating the specific processes implicated to find more effective therapeutic options. PGE2, acting ...
متن کاملIdentification and localization of prostaglandin E2 receptors in upper and lower segment human myometrium during pregnancy.
Prostaglandin E2 (PGE2) plays a key role in the maintenance of human pregnancy and labour onset. PGE2 can elicit diverse actions within the uterus depending on the PGE2 receptors (EP1, EP2, EP3 and EP4) expressed. By signalling through different intracellular pathways the EP receptors may inhibit or promote smooth muscle contractility. Nine different EP3 receptor splice variants have been ident...
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OBJECTIVES To investigate the expression of prostaglandin E2 receptor subtypes, E-prostanoid (EP) 1-4 receptors, in acquired cholesteatoma and its possible role in the pathologic process of this disorder. METHODS Specimens of human acquired cholesteatoma were obtained from 29 patients and 19 skin biopsies of normal external auditory canal were as controls. The mRNA and protein expression of E...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1998
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.95.26.15792